葛亮

葛亮

博士 研究员，助理教授

2001-2005年，山东师范大学生命科学院                  学士

2005-2011年，中科院上海生化细胞所                      生物化学博士

2011-2015年，美国加州大学伯克利分校                  博士后

2015-2017年，美国加州大学伯克利分校                  研究员（Research Specialist）

2017-               清华大学生命科学学院-生命科学联合中心  助理教授，  研究员

● 研究兴趣、领域：

细胞自噬是细胞内物质自我清理和更新的重要机制，与衰老和许多重大疾病密切相关。我们运用最新的细胞生物学和生物化学手段研究细胞自噬的分子机制和生物学功能，集中于自噬体膜形成的分子机制，以及其调节毒性蛋白聚集体的降解和非典型分泌的研究。我们也同时致力于细胞自噬对细胞内稳态维持以及相关重大疾病（如癌症和神经退行疾病）的研究。

● 代表性论文：

1. Liang Ge*, Min Zhang, Sam Kenny, Anandita Mathur, Dawei Liu, Miharu Maeda, Kota Saito, Ke Xu, and Randy Schekman. Remodeling of ER-exit sites initiates a membrane supply pathway for autophagosome biogenesis. EMBO Report (2017) 18(9):1586-1603. * Corresponding author.

2. Livia W Brier, Min Zhang, Liang Ge*. Mechanistically dissecting autophagy: insights from in vitro reconstitution. J Mol Biol (2016) 8;428(9 Pt A):1700-13.*Corresponding author

3. Liang Ge, Livia Wilz and Randy Schekman. Biogenesis of autophagosomal precursors for LC3 lipidation from the ER-Golgi intermediate compartment. Autophagy (2015) 11(12):2372-4

4. Liang Ge, Min Zhang and Randy Schekman. Phosphatidylinositol 3-kinase and COPII generate LC3 lipidation vesicles from the ER-Golgi intermediate compartment. eLife (2014) Nov 28; 3:e04135.

5. Liang Ge, Sulochanadevi Baskaran, Randy Schekman and James H Hurley. The protein-vesicle network of autophagy. Curr Opin Cell Biol (2014) 29C:18-24.

6. Liang Ge and Randy Schekman. The ER-Golgi intermediate compartment feeds the phagophore membrane. Autophagy (2013) 10(1):170-2

7. Liang Ge, David Melville, Min Zhang and Randy Schekman. The ER-Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis. eLife (2013) Aug 6; 2:e00947. Selected for F1000Prime and highlighted by Daniel Klionsky [Amélie Bernard and Daniel J Klionsky. Defining the membrane precursor supporting the nucleation of the phagophore. Autophagy (2014) 10(1):1-2].

8. Liang Ge, Wei Qi, Li-Juan Wang, Hong-Hua Miao, Yu-Xiu Qu, Bo-Liang Li and Bao-Liang Song. Flotillins play an essential role in Niemann-Pick C1 Like 1-mediated cholesterol uptake. Proc Natl Acad Sci USA (2011) 108(2):551-556

9. Liang Ge, Jing Wang, Wei Qi, Hong-Hua Miao, Jian Cao, Yu-Xiu Qu, Bo-Liang Li and Bao-Liang Song. The cholesterol absorption inhibitor Ezetimibe acts by blocking the sterol-induced internalization of NPC1L1. Cell Metabolism (2008) 7:508-519. Selected for F1000Prime;Featured Article; Commented in Cell Metabolism (2008) 7:469-471

10.Jin-Hui Zhang*, Liang Ge*, Wei Qi, Liqing Zhang, Hong-Hua Miao, Bo-Liang Li, Maojun Yang and Bao-Liang Song. The N-terminal domain of NPC1L1 protein binds cholesterol and plays essential roles in cholesterol uptake. J Biol Chem (2011) 286(28):25088-097            *Equal contribution

11.Bei-Bei Chu*, Liang Ge*, Yang Zhao, Jing Wang, Bo-Liang Li and Bao-Liang Song. Requirement of myosin Vb·Rab11a·Rab11-FIP2 complex in cholesterol-regulated translocation of NPC1L1 to the cell surface. J Biol Chem (2009) 284(33):22481-90.  *Equal contribution

12.Min Zhang, Dawei Liu, and Liang Ge*. In vitro dissection of autophagy. Curr Protoc Cell Biol (2017), 77, 11.23.1–11.23.17. doi: 10.1002/cpcb.33

● 荣誉、奖励及参加学术团体的情况：

NIH Pathway to Independence Award (K99/R00) (2015-2017)

Jane Coffin Child Foundation Fellowship (2013-2015)

Human Frontier Science Program Fellowship (2012)

● 联系方式：

电话：86-10-62789019 (实验室)      

E-mail: liangge@mail.tsinghua.edu.cn